Multi-user detection for multi-carrier communication systems

Doctor of PhilosophyDepartment of Electrical and Computer EngineeringBalasubramaniam NatarajanWireless broadband communications is a rapidly growing industry. New enabling technologies such as multi-carrier code division multiple access (MC-CDMA) are shaping the future of wireless systems. However, research efforts in improving MC-CDMA receiver performance have received limited attention and there is a need for innovative receiver designs for next generation MC-CDMA. In this thesis, we propose novel multi-user detection (MUD) schemes to enhance the performance of both synchronous and asynchronous MC-CDMA. First, we adapt the ant colony optimization (ACO) approach to solve the optimal MUD problem in MC-CDMA systems. Our simulations indicate that the ACO based MUD converges to the optimal BER performance in relatively few iterations providing more that 95% savings in computational complexity. Second, we propose a new MUD structure specifically for asynchronous MC-CDMA. Previously proposed MUDs for asynchronous MC-CDMA perform the detection for one user (desired user) at a time, mandating multiple runs of the algorithm to detect all users' symbols. In this thesis, for the first time we present a MUD structure that detects all users' symbols simultaneously in one run by extending the receiver's integration window to capture the energy scattered in two consecutive symbol durations. We derive the optimal, decorrelator and minimum mean square error (MMSE) MUD for the extended window case. Our simulations demonstrate that the proposed MUD structures not only perform similar to a MUD that detects one user at a time, but its computational complexity is significantly lower. Finally, we extend the MUD ideas to multicarrier implementation of single carrier systems. Specifically, we employ the novel MUD structure as a multi-symbol detection scheme in CI-CDMA and illustrate the resulting performance gain via simulations

MULTIUSER DETECTION FOR MULTICARRIER COMMUNICATION SYSTEMS

Wireless broadband communications is a rapidly growing industry. New enabling technolo-gies such as multi-carrier code division multiple access (MC-CDMA) are shaping the future of wireless systems. However, research efforts in improving MC-CDMA receiver performance have received limited attention and there is a need for innovative receiver designs for next gen-eration MC-CDMA. In this thesis, we propose novel multi-user detection (MUD) schemes to enhance the performance of both synchronous and asynchronous MC-CDMA. First, we adapt the ant colony optimization (ACO) approach to solve the optimal MUD problem in MC-CDMA systems. Our simulations indicate that the ACO based MUD converges to the optimal BER performance in relatively few iterations providing more that 95 % savings in computational complexity. Second, we propose a new MUD structure specifically for asynchronous MC-CDMA. Previ-ously proposed MUDs for asynchronous MC-CDMA perform the detection for one user (desired user) at a time, mandating multiple runs of the algorithm to detect all users ’ symbols. In this thesis, for the first time we present a MUD structure that detects all users ’ symbols simultane-ously in one run by extending the receiver’s integration window to capture the energy scattered in two consecutive symbol durations. We derive the optimal, decorrelator and minimum mean square error (MMSE) MUD for the extended window case. Our simulations demonstrate that the proposed MUD structures not only perform similar to a MUD that detects one user at a time, but its computational complexity is significantly lower. Finally, we extend the MUD ideas to multicarrier implementation of single carrier systems. Specifically, we employ the novel MUD structure as a multi-symbol detection scheme in CI-CDMA and illustrate the resulting performance gain via simulations

Aortic atherosclerosis as an embolic source

Stroke is the third leading cause of death in several industrial countries and cardiogenic embolism accounts for 15\u201330 % of ischaemic strokes [1\u20135]. The diagnosis of a cardioembolic source of stroke is frequently uncertain and relies on the identification of a potential cardiac source of embolism in the absence of significant autochthonous cerebrovascular occlusive disease. In this regard, echocardiography (either transthoracic \u2013 TTE or Transoesophageal \u2013 TEE) serves as a cornerstone in the evaluation and diagnosis of these patients [6, 7]

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research